Hiroaki Namba , a professor at Kobe Pharmaceutical University in Japan, is the leading figure in Maitake research and is well-known in the world. He compared the efficacy of Maitake with other fungi and published many research results. In the related experiments on tumor suppression, Professor Hiraki Namba used mice on the ninth day after tumor transplantation. The result showed that the tumor suppression rate of Maitake D component reached 86.0%, and the dosage was 0.5 mg/kg, which confirmed Maitake It is a very effective anti-tumor drug.
In 1986, Professor Hiroaki Namba published a research report on "Griver Grifola" in the Japanese Pharmaceutical Journal. The report pointed out: Maitake polysaccharides have 4 kinds of A, B, C and D. Although they all have anti-tumor effects, the effect of D component is better. Although its content in Maitake is not high, its anti-tumor activity is stronger than general anti-tumor drugs, and it does not have any side effects. Subsequently, Hiraki Namba successfully extracted the D component of Maitake for the first time in the world, which attracted the attention of the world medical community.
Maitake D component has better anti-cancer effect
Maitake contains β-(1-6) binding as the main chain and β-(1-3) binding as the side chain glucan and β-(1-3) binding as the main chain and β-(1-3) binding as the main chain. -(1-6) Active glucan combined as a side chain. Experiments have shown that these active glucans can significantly inhibit tumor growth by activating immune function; at the same time, it has been found that purified active glucans can only be effective by injection, while Maitake D component (active glucan and protein Conjugate) The desired effect can be obtained by oral administration. The D component of Maitake is different from similar substances extracted from shiitake mushrooms, Yunzhi and other mushrooms in terms of chemical structure and composition or molecular weight, and its biological activity is also unmatched by these similar substances. Maitake polysaccharide induces tumor cell apoptosis by inhibiting oncogenes and activating immune cells in the body, so it has no toxic side effects. Moreover, when it is combined with chemotherapy drugs, it can significantly reduce the immunosuppression, nausea and vomiting caused by chemical drugs.
Animal experiments and clinical experiments have shown that Maitake D component exerts anti-cancer and anti-cancer effects through the following aspects: activation of phagocytes, natural killer cells, and cytotoxic secretion; inducing cancer cell apoptosis; and traditional The combination of chemotherapeutic drugs (mitomycin, camostine, etc.) not only increases the efficacy, but also reduces the side effects of chemotherapy; It has a synergistic effect with immunotherapy drugs (interferon-βSlows the late stage The pain of cancer patients increases appetite and improves the quality of life of patients.
