Maitake, also known as chestnut mushroom and shellfish leaf porous fungus, is a rare edible fungus for both medicine and food. Maitake polysaccharide is isolated from the fruit body of Maitake. The main component is fungal polysaccharide, which has the effects of enhancing immunity, inhibiting tumor, anti human immunodeficiency virus, stabilizing blood pressure and so on.
Spleen deficiency syndrome not only has the changes of digestive function such as loose stool, diarrhea, emaciation and biochemical deficiency of Qi and blood, but also its immune function is affected. The essence of spleen deficiency is closely related to the low immune function. As a natural immune regulator, Maitake polysaccharide can regulate the immune depression caused by spleen deficiency syndrome.
Maitake polysaccharide can promote Th1 cells to produce IFN- γ。 IFN- γ It is mainly produced by activated NK cells and T cells, which can induce cells to express IL-2 receptor, thus promoting T cell proliferation and further expanding immune response; It can also enhance the ability of cytotoxic T cells (CTL) and NK cells to kill target cells, and has the effect of macrophage activating factor (MAF). IL-4 is mainly produced by activated T cells, mast cells and basophils. It is the most representative Th2 cytokine. IFN- γ And IL-4, as a pair of important regulatory factors in the immune system, play an important role in maintaining the balance of th1/th2 in cd4+t cell subsets.
Some studies have explored the regulatory mechanism of Maitake polysaccharide on immune function in spleen deficiency mice. The imbalance of th1/th2 cytokine network exists in mice with spleen deficiency, which weakens the body's defense, and reduces its anti infection and anti-tumor effects. Maitake polysaccharide can effectively increase IFN in serum of spleen deficiency mice- γ Content, down regulate the content of IL-4, so as to balance th1/th2 subpopulations and transform Th2 cells into Th1 cells, so as to achieve the purpose of treating spleen deficiency syndrome.
Source: China Edible Fungi Association
