The antitumor and antiviral pharmacological activities of Maitake polysaccharide are related to its activation of the immune system and regulation of immune function.
Maitake polysaccharide can improve the immunity of the body in many ways. It can not only improve the non-specific immunity of the body, but also improve the specific immune function of the body. It can activate natural killer cells (NK) and cytotoxic T cells, promote the phagocytic activity of macrophages, and stimulate macrophages to accelerate the release of cytokines.
Component D of Maitake has immune activation effect on mice, so that natural killer cells, cytotoxic T cells and late sensitive T cells in mice are activated by 1.5~2.2 times, and the contents of IL-1, IL-2 and superoxide anion are increased to varying degrees, and both intraperitoneal injection and oral and abdominal injection are effective.
Maitake polysaccharides treated by chemical crosslinking can bypass the complement components and directly promote M Ф Activity, increase the number of peritoneal attachment cells, improve delayed anaphylaxis, improve the induction of T cells, and enhance the cytotoxicity of antigen-dependent specific killer cells (TC) to tumor cells α。
Oral administration of Maitake homopolysaccharide pgf-1 can comprehensively enhance the non-specific immunity, cellular immunity and humoral immunity of tumor bearing mice, that is, it can not only significantly increase the weight of immune organs of tumor bearing mice, but also significantly enhance the delayed type hypersensitivity induced by 1% dinitrofluorobenzene (DNFB), improve the lymphocyte transformation ability and spleen antibody production ability of tumor bearing mice, as well as the content of serum hemolysin IgG and IgM.
No (nitric oxide) is an important factor in the antibacterial and antitumor activity of macrophages. Maitake polysaccharide can enhance the synthesis of no in peritoneal macrophages (PM) in vitro, and can γ In the presence of interferon, it stimulates the synthesis of no in pp-pec (protein peptide induced peritoneal macrophase); Maitake polysaccharide improves the liver of rats γ The expression of interferon mRNA indicates that Maitake polysaccharide may pass through γ Interferon mediated mechanism promotes NO synthesis in vivo. Maitake polysaccharide promotes the release of cytokines, which is related to the synthesis of no and its activation of Kupffer cells. A large amount of no was detected in the supernatant of spleen cells cultured in vitro. When NMMA, an inhibitor of NO synthase, was added to the culture process, it was found that the concentration of antibody in the supernatant was significantly higher than that in the control group (without NMMA), suggesting that the production of antibody was not necessarily related to the formation of No.
