How to prevent tumor recurrence, how to prevent tumor recurrence, how to prevent tumor recurrence, how to prevent tumor recurrence
Is chemotherapy really that terrible? People often talk about cancer color change, but also talk about "transformation" color change. In fact, at present, some people in the society have misunderstood or exaggerated the side effects of chemotherapy and neglected the role of chemotherapy in the active treatment of malignant tumors. "The patient could have survived, but chemotherapy hurt him!" The side effects of chemotherapy spread in the market are daunting.
People fall into two extremes in their understanding of chemotherapy. They are either too afraid of chemotherapy and the side effects of chemotherapy; Or believe too much in the effect of chemotherapy and think that everything will be fine after the completion of chemotherapy! In fact, chemotherapy can be said to be a double-edged sword. As long as doctors apply it properly and patients cooperate with treatment, it can cure the sick and save people. The advantages outweigh the disadvantages!
To treat chemotherapy correctly, cancer patients should seek advantages and avoid disadvantages
As a systemic treatment method, chemotherapy is the main means of tumor treatment at present. No matter what route of Administration (oral administration, intravenous administration, body cavity administration, etc.), chemotherapy drugs will spread throughout most organs and tissues of the body with the blood circulation. Early, middle and late stage patients need chemotherapy, especially chemotherapy sensitive tumors, such as lymphoma and leukemia.
Because many patients are afraid of the side effects of chemotherapy, leukopenia, hair loss, vomiting and other symptoms caused by long-term chemotherapy, and fear that it is difficult to kill all tumor cells, they are particularly troubled about whether to do chemotherapy. In fact, experts said that the key lies in how to "pursue advantages and avoid disadvantages". When the chemotherapy is carried out, it must be carried out in time, not too tangled with the so-called side effects of chemotherapy. For cancer species and patients suitable for chemotherapy, the advantages far outweigh the disadvantages.
As long as the chemotherapy is combined with a comprehensive treatment plan, the best anti-tumor effect is achieved, and the adverse reactions of chemotherapy drugs are prevented and reduced, the chemotherapy will achieve a good anti-cancer effect. Moreover, with the rapid development of molecular targeted therapy, immune checkpoint inhibitor and cellular immunotherapy, the advantages of chemotherapy have been gradually weakened. In most cases, doctors will carry out multidisciplinary comprehensive treatment, and chemotherapy will work together with radiotherapy, targeted therapy, immunotherapy and other treatment methods to strive for greater clinical benefits.
In 1998, the World Health Organization pointed out that:
Appropriate chemotherapy has become a radical treatment for some tumors:
Malignant trophoblastic tumor, acute lymphoblastic leukemia, Hodgkin lymphoma, non Hodgkin lymphoma, testicular cancer, acute myeloid leukemia, embryonic rhabdomyosarcoma, neuroblastoma, small cell lung cancer and ovarian cancer;
Tumors that may be cured after adjuvant chemotherapy:
Breast cancer, osteosarcoma, colorectal cancer, osteosarcoma, retinoblastoma, soft tissue sarcoma and nephroblastoma.
Palliative effect of chemotherapy in some advanced tumors (prolonging patients' life, alleviating symptoms and suffering, etc.):
Gastric cancer, esophageal cancer, non-small cell lung cancer, head and neck cancer, kidney cancer, melanoma, prostate cancer, endometrial cancer, etc.
What should I do after chemotherapy? Treatment of side effects and prevention of recurrence are indispensable
When it comes to the side effects of chemotherapy, cancer friends will have many misunderstandings. The greater the side effect is, the better the effect is, and the size of the side effect cannot be equated with the efficacy. The worse the chemotherapy effect of some patients after relapse is because the cancer cells in the body have developed resistance to chemotherapy.
Common side effects include nausea and vomiting, hair loss, diarrhea or constipation, numbness / tingling in hands and feet, bone marrow suppression, taste change or loss of appetite, oral ulcer, anemia, skin and nail changes, infection / fever, and fatigue. In fact, almost all common side effects of chemotherapy have corresponding medical countermeasures.
Some adjuvant drugs of chemotherapy have been developed greatly in recent years. At present, there have been more effective preventive and antagonistic drugs for chemotherapy reactions commonly feared by patients, such as vomiting and leucopenia, which greatly improves the tolerance of patients to chemotherapy. There are some ways to help patients feel better. Through good symptomatic and drug treatment, the side effects of chemotherapy can be controlled or reduced. Chemotherapy can cause a variety of side effects (adverse reactions) in the body, and not everyone will experience every side effect. There are individual differences, which are not directly related to the treatment effect. If there are side effects, it doesn't matter. Many side effects and physical changes can be recovered.
So what do cancer patients need in the face of the side effects of chemotherapy? Zhangxiaotian, director of internal medicine of Peking University Cancer Hospital, said that nutrition is very important for cancer patients, especially chemotherapy patients. However, in the actual treatment, 80% of cancer patients have weight loss, 40% of patients have weight loss of more than 10%, and 31%-87% of cancer patients have obvious malnutrition.
Chemotherapy is closely related to nutrition. On the one hand, chemotherapy can fundamentally improve the nutritional status of patients through anti-tumor effect. However, the adverse reactions will increase the malnutrition of patients themselves.
Therefore, if we want to maintain a balance between chemotherapy and nutrition, we need to find ways to solve the problem of malnutrition. In order to help cancer patients better understand the relationship between nutrition and cancer, and find better ways to supplement nutrition, cancer free home medical department and domestic authoritative tumor nutrition experts consult with cancer patients from time to time to formulate nutrition treatment methods.
In addition, after a person has cancer, if the patient has strong immunity when receiving appropriate treatment, the treatment effect will be better than that of the person with weak immunity. Moreover, in the process of cancer, it is also very important to improve self immunity, because to repair normal cells and make the body play an immune role, in addition to attacking cancer cells, it also needs to protect and repair body functions. Therefore, in short, the relationship between immunity and cancer cells is like a spring. If you are strong, I will be weak, and if I am strong, you will be weak.
The relationship between immunity and cancer can be summarized as follows: low immunity → chronic inflammation → cell mutation → occurrence and development of cancer → further decline of immunity → tumor formation by cancer cells → increasingly poor immunity → progress and metastasis of cancer → complete collapse of immunity → complete over of the body. This is a vicious circle. Breaking it requires starting from the source - enhancing the body's immunity!
If conditions permit, it is better to use thymosin to improve immunity
In addition to the above-mentioned measures to improve immunity, Professor lixianliang also mentioned in the "reading" column of CCTV science and education channel that thymosin can be used to improve immunity.
CCTV reports on thymosin
Speaking of thymosin, you may be a little strange. In fact, during the SARS period in 2003, all the military doctors in Xiaotangshan injected thymosin, and eventually no one was infected.
During the COVID-19, all the medical teams sent by the army also received thymosin, which can improve lymphocyte subpopulations and immunity. Therefore, the infection rate of the medical personnel supported during the anti epidemic period is very low. In clinic, many tumor patients are also treated with thymosin to improve immunity.
Thymosin (also known as thymosin, thymosin) is a group of peptides with physiological activities secreted by thymus tissue. Contains a variety of hormones, belonging to α、β、γ Three types, which together induce the maturation and differentiation of T cells. Thymic peptides commonly used in clinic are small molecular peptides with nonspecific immune effects found and purified from calf thymus.
Three roles of thymosin
1. continuously induce the differentiation and development of T cells in vivo, and finally form a large number of T cells with killing ability
2. maintain the immune balance of the body and enhance the recognition and killing ability of T cells to antigens
3. improve the body's ability to resist diseases
So, how to quickly and easily repair the immune system, enhance immunity and assist in subsequent treatment?
Oral thymosin peptide powder is a wise choice. It contains thymosin peptide and soybean peptide powder, which can increase the reserve of immune cells and activate the immune system.
To supplement immunity at any time can lay the foundation for subsequent cancer treatment. Anti cancer is a long-term battle, and persistence can win!
Attention should be paid to maintaining and improving the physical state of patients, and both sleep and exercise should be taken into account
All patients will encounter important problems in chemotherapy. How to maintain and improve the physical state of patients is often ignored by patients and their families. In particular, cancer patients often have obvious physical decline, feel tired and weak, and are not valued by everyone. They think that "keeping" is OK. This idea is absolutely unacceptable.
There are two commonly used scores to measure physical status, ECoG score and KPS score. The ECoG score is usually used as one of the recruitment conditions for subsequent relapses to participate in clinical trials. The ECoG score of recruited patients is usually required to be 0~1.
ECoG scoring standard
Good physical condition is very important for treatment.
1. it can affect the smooth progress of treatment and the curative effect.
2. patients with worse physical condition tend to have decreased immune function, and the recurrence and metastasis rate of tumor is likely to increase. Therefore, patients and their families should have the awareness of maintaining and improving physical strength. They should start from the first day of diagnosis of tumors. Fighting malignant tumors is like a battle. Maintaining good physical strength is one of the key factors to win. How to maintain and improve physical condition and reduce fatigue and weakness? This requires a systematic and comprehensive response, the joint efforts of the patients themselves, their families and the attending doctors, and involves many aspects.
It is mainly divided into nutritional support, treatment of side effects of chemotherapy drugs, sleep improvement, anemia correction, exercise, infection prevention, psychological counseling, treatment of cancer pain, etc. the editor will explain in detail to cancer friends in the follow-up popular science. Patients who have any questions or do not know how to improve their personal physical conditions can consult the cancer free home medical department, which will help to develop strategies to enhance immunity Coping plan for physical recovery.
What if unfortunately the disease recurs? Try to participate in clinical trials and actively seek new solutions
In real life, when many cancer friends hear about clinical trials, their first reaction is "you let me participate in clinical trials, don't you take me as a mouse?" "I did a clinical trial. In case I was assigned to the placebo group, could I not get effective treatment?"
Not really! Due to the late start of clinical trials in China, many people are biased and do not understand the trial drugs in clinical trials. In fact, in Europe and the United States, many patients will take the initiative to consult doctors about whether they have their own clinical trials.
A clinical trial is a study designed to evaluate potential new treatments. Clinical trials test the safety and effectiveness of new or improved cancer drugs, new drug doses, unique surgical or radiotherapy methods, and various treatment combinations.
Clinical trials are applicable to most types and stages of cancer. For cancer with poor effect of current standard therapies, clinical trials are particularly important. The potential benefits of participating in clinical trials include close monitoring, the possibility of obtaining promising treatments as soon as possible, and knowing that they are contributing to the progress of cancer treatment. However, the disadvantage is that the new treatment may not be satisfactory, or unexpected side effects may be found. If you are considering participating in a clinical trial, your treatment team may help you balance the risks and benefits.
The clinical recruitment of Chinese independently developed chemotherapy drug legubicin is in progress
When it comes to "chemotherapeutic drugs", we have to talk about the pan cancer chemotherapeutic new drug legubicin independently developed in China. Compared with doxorubicin, this drug has less damage to normal cells, less cardiotoxicity, allergy, hemolysis, vascular and muscle irritation, higher safety, and has significant efficacy against a variety of solid tumors, which is expected to benefit more patients.
However, in the study on the mouse model of glioblastoma of cerebrum stellatum, the curative effect of legubicin was stronger than that of doxorubicin in the case of effective drug content.
In addition, the results in the mouse model showed that the complete response rate of doxorubicin +pd-1 was 12.5%, and that of legumin +pd-1 was 87.5%.
That is to say, the complete remission rate of the combination therapy of lacubicin is 7 times higher than that of doxorubicin!
At present, legubicin has been recognized as a new chemical class 1 drug and has been approved by the State Drug Administration for clinical trials (2018l02645), allowing clinical trials. Recently, the "phase II" clinical trial of legubicin began to recruit patients! Therefore, you can contact the cancer free home medical department for consultation, and professional medical consultants will guide you to make choices.
How to prevent recurrence? Mobilize the immune corps to regulate immunity
The immune function of tumor patients is in an abnormal state, and surgery, radiotherapy and chemotherapy will cause certain damage to the immune function of the human body. After clinical treatment, adjusting the immune function as soon as possible is the top priority to prevent recurrence and metastasis.
In addition to diet, exercise and other daily life styles, the regulation of immune function also needs clinical treatment to help us recover as soon as possible, such as the injection of thymic peptide drugs and interferon, as well as various cell immune reinfusion to restore immune test function and immune killing function.
NK cell therapy
In addition to car-t therapy, there are also well-known NK cells (natural killer cells), which have great potential in tumor immunotherapy. At present, NK cell strategies for tumor immunotherapy include: in vitro activated autologous or allogeneic NK cell therapy; Combination of NK cells and monoclonal antibodies (such as immune checkpoint inhibitors) to induce antibody specific cytotoxicity; Construct car-nk cell immunotherapy.
dendritic cell vaccine
Dendritic cells (DCS) are the most powerful antigen-presenting cells known in the body. Their greatest feature is that they can stimulate the proliferation of initial T cells. Therefore, DC is the initiator of immune response and plays a unique role in the induction of immune response. Dendritic cells can fully activate T cells in vivo and promote the clearance of tumor by T cells. Dendritic cells can also promote the enrichment of T cells and enhance the activation of T cells.
DC vaccine has been widely recognized by the international medical anti-tumor field, and has been used in the clinical treatment of a variety of cancers, which is a new hope for the treatment of cancer patients. In addition, Germany and Japan also have dendritic cell vaccine for clinical adjuvant treatment of a variety of cancers, such as lung cancer, liver cancer, kidney cancer, breast cancer, skin cancer, etc. Patients who want to seek help from new treatment technologies at home and abroad can first submit their medical records to the cancer free home medical department for preliminary evaluation.
CTL (cytotoxic T lymphocyte) therapy
For the vast number of patients with advanced cancer who cannot be operated on, what cell therapy can be used as an adjuvant therapy?
In recent years, researchers have been developing new immunotherapy schemes for these patients, including CTL (cytotoxic T lymphocytes) technology, namely cytotoxic T lymphocytes. This technology mainly uses the proteins unique to cancer cells and absent or low in normal cells as bait to select the "one in a million" truly anti-cancer lymphocytes in peripheral blood, and then further improve and expand them in vitro, and then transfuse them to patients.
Mtca-ctl immunotherapy is a new generation of biological immunotherapy mode launched in China. While ensuring the expansion of non MHC restricted killer NK-T cells, directionally expand HC restricted cd8+ specific CTL cells, so that their ratio in cell products can reach 60%~70%. The combined action of these killer cells makes the efficiency of killing tumor cells higher.
CTL therapy treatment data
The multi-target compound antigen peptide biological immunotherapy technology currently undergoing phase II clinical trial in the Cancer Hospital of the Chinese Academy of Medical Sciences is the fifth and new generation of cellular immunotherapy technology, which can optimize the activation method of DC (dendritic cells) to enhance the killing effect of immune cells on tumor cells. At present, it has achieved good clinical results, and it is believed that it will truly benefit cancer patients.
[mainly applicable to solid tumors] head and neck tumors, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, membranous adenocarcinoma, colon cancer, ovarian cancer, uterine cancer, comet cancer, prostate cancer, malignant melanoma, sarcoma and some malignant lymphoma.
If you want to consult mtca-ctl therapy, you can contact the cancer free home medical department to assess your condition in detail.
When encountering treatment bottleneck, actively seek second diagnosis and treatment advice
Another step many cancer patients take when choosing a doctor or treatment plan is to obtain a second opinion from another expert in the field. In any complex medical field, second opinion is a common practice, and there are many treatment options. Getting a second opinion can help you better understand the treatment of cancer, and it can also provide a kind of comfort.
If two experts who treat your cancer type reach an agreement on the treatment plan, it may help you feel more confident about your treatment choice. If the experts disagree, it may open another door for the diagnosis and treatment of the disease.
Article source:
http://www.globecancer.com/azzx/show.php?itemid=14957
