If the 20th century is the era of drug therapy, then the 21st century is the era of cell therapy—— American biologist George Daley
In recent years, with the outbreak of the epidemic, more and more people began to pay attention to their own health and the improvement of immunity.
The main foundation of immunity is immune cells, which play different roles. They can distinguish and recognize bacteria, viruses and other pathogens invading from the outside, and play an important role in stabilizing the health of the body in the human body.
But can we treat its application value in disease intervention objectively? How does this emerging technology help people improve their quality of life? Who is suitable for using immune cells?
The application of immune cells is analyzed with 10 groups of questions and answers below.
01 what is immune cell
Immune cells refer to cells involved in or related to immune response. There are many kinds of them, such as T cells, NK cells, macrophages, dendritic cells, B cells and so on. Their quantity and quality are closely related to human health.
Immune cells mainly exist in blood and tissues, play a role in resisting the invasion of bacteria and viruses, and can timely remove pathological changes, aging, and even cancerous cells, and kill tumor cells.
02 what are the immune cells prepared in the laboratory
The classification of immune cells is extremely complex, and the main extraction method comes from human peripheral blood. The most common are NK cells, CIK cells; Cancer patients will use DC cells, til cells, and very few solid tumor patients will use car-t cells.
NK cells
NK cells (natural killer cells) are known as the "first line of defense" of human health. As one of the indicators to judge the anti-tumor and anti-virus infection of the body, it is mainly used for the prevention and treatment of immune deficiency diseases and solid tumors.
NK cells (blue markers) are attacking ovarian cancer cells
NK cells (blue markers) tear ovarian cancer cells apart
The most powerful thing about NK cells is that they can directly and quickly (within 5 minutes) annihilate foreign bodies (viruses, bacteria, infected cells, cancer cells, aging cells, etc.) without the need for antigen presentation process and other people's information. At the same time, they can activate phagocytes, increase their ability to clean up aging cells, and efficiently and intensively protect our bodies from damage, so as to delay aging The purpose of keeping young.
CIK cells
CIK cells are human immune commandos, whose full name is cytokine induced killer. It is a group of heterogeneous cells obtained from human peripheral venous blood mononuclear cells cultured in vitro. It is mainly used for the removal of small residual lesions after surgery and radiotherapy and chemotherapy.
DC cell
DC cells, also known as dendritic cells, as immune scouts, are the strongest antigen-presenting cells in the human body. They are mainly used to regulate and maintain immune response and antigen presentation, and do not directly kill cells.
DC cell
Til cells
Til cells, also known as tumor infiltrating lymphocytes, are tumor killing special forces. As a new type of anti-tumor effector cell, it mainly acts on primary or secondary tumors in skin, kidney, lung, head and neck, liver and ovary.
Car-t cell
Car-t cells, also known as chimeric antigen receptor T cells, can be regarded as tumor killing beheaders. In recent years, through optimization and improvement, it can attack accurately, quickly and efficiently in clinical anti-tumor, and has achieved good results. It is a very promising immune cell.
Car-t cell
Car-t cells, also known as chimeric antigen receptor T cells, can be regarded as tumor killing beheaders. In recent years, through optimization and improvement, it can attack accurately, quickly and efficiently in clinical anti-tumor, and has achieved good results. It is a very promising immune cell.
03 immune adoptive reinfusion technology based on NK cells
With the growth of age, the immune function of the body is gradually degraded, which is the law of natural evolution. NK cells cannot escape this disaster, and their number and activity will decrease accordingly.
Especially after the age of 40, the number, activity and tumor killing ability of NK cells will gradually decrease; By the age of 60, it will drop to 50% of the function of young people. It is conceivable that at this time, how poor the whole immune function of the human body is, the risk of disease infection will increase significantly.
Therefore, researchers are now developing various methods to release the anti-virus and anti infection activity of NK cells, so as to improve the efficacy and specificity of NK cells. At present, the anti-aging immune strategy based on NK cells is mainly the "adoptive" reinfusion of autologous or allogeneic NK cells activated in vitro for anti-aging and other applications.
Immune cell technology is to collect human peripheral blood immune cells, expand and culture them in vitro, increase their number thousands of times, enhance the targeted killing function, and then transfuse them back into the human body to kill pathogens, aging cells, mutant cells in blood and tissues, break the original immune tolerance, activate and enhance the immune capacity of the body.
This has been proved to be safe, and unlike T cell applications, NK cells do not cause graft-versus-host disease to recipient tissues.
04 what are the outstanding advantages of immune cell conditioning
No.1 has wide indications
It can effectively intervene most diseases and eliminate tumor cells that are insensitive to radiotherapy and chemotherapy and metastasize;
No.2 safety
Using human autoimmune cells to kill pathological cells, there are almost no toxic and side effects;
No.3 persistence
Help the human body activate the body's immune system, restore the body's immune function, and permanently kill diseased cells;
No.4 thoroughness
Improve the immune ability of the body, completely remove the residual "zombie" cells and micro metastatic lesions in the body;
No.5 pertinence
DC cells specifically recognize tumor cells, and CIK cells nonspecifically kill broad-spectrum tumor cells;
No.6 comprehensiveness
Rebuild and improve the immune function of patients, comprehensively identify, search and kill pathological cells, and effectively prevent the recurrence and metastasis of the disease.
05 is there any side effect of immune cell reinfusion
Immune cell reinfusion is conditioned by immune cells produced by the human body itself, which will not produce toxic side effects and rejection.
The cultured cells have been subjected to many strict and multiple tests. They are safe and reliable, and will not produce dependence.
06 what are the taboos of immune cell conditioning
It should be noted that some people cannot use immune cells for conditioning due to special circumstances, as follows:
Organ transplant due to immune system;
T-cell lymphoma patients;
Severe autoimmune diseases;
Patients with uncontrollable infectious diseases;
Have a history of severe allergy or severe viral bacterial infection;
Pregnant or lactating women;
For patients with organ failure, the specific organ standards are as follows:
Heart: above grade IV;
Liver: reach the domestic liver function grade C or above;
Kidney: renal failure and uremia;
Lung: severe respiratory failure symptoms, involving other organs, such as liver and kidney function;
Brain and brain metastasis with consciousness disorder;
Patients with obvious autoimmune dysfunction clinically.
07 how effective is immune cell conditioning
Immune cell conditioning is through in vitro culture, proliferation, activation, and reinfusion into the human body to induce the autologous antiviral immune response. Once the human antiviral immunity is activated, it will continue to produce antiviral substances to kill the virus.
Its main functions are:
01 balance immune disorders and improve immunity
02 prevention and control of major diseases
03 improve sub-health and aging caused by blood system
04 rebuild the immune system
Figure: in 2013, science listed immune cell technology as one of the top ten breakthroughs in science that year, and believed that it marked the complete transformation of disease intervention methods. Domestic experts also said that cellular immune technology will set off a new medical revolution in the future.
08 the reinfusion of immune cells usually takes several cycles
The regulation of immune cell reinfusion is closely related to the individual situation of users. Because everyone has different physiques and conditions, professional doctors will customize a more accurate cell use scheme according to the user's various physical indicators and repair effects.
According to the specific repair plan, it usually starts from 1-3 cycles.
09 what is the difference between immune cell therapy and traditional methods
Traditional surgical intervention has some disadvantages, and there are also sequelae and functional obstacles after operation, which have a great impact on the recovery of tissues and organs; Moreover, there are certain risks in surgery, that is, the risk of accelerated metastasis and recurrence caused by surgical trauma, which we cannot ignore.
Immune cells can identify the enemy and ourselves, have strong lethality, find out the cancer cells with hidden antigens faster, and can directly attack and destroy the diseased cells. They also have a certain repair effect on the cells or tissues damaged by anticancer agents and rays.
10 At what age can people with a family history of cancer do immune cell reinfusion?
Other schemes to enhance resistance can only aim at their existing immune cells, which have the ability to regulate, antiviral and defend against viruses. Immune cells can not only comprehensively improve the body's immunity, but also actively identify and eliminate any foreign bodies (viruses, bacteria, etc.) invaded by foreigners. At the same time, they also have the ability to identify and deal with mutant cells and virus infected cells in the body.
As immune cells extracted from their own blood, it is recommended that all those who have a family history of cancer and tumor should go to the hospital for tumor screening as soon as possible. The sooner they are applied and prevented, the better.
The treatment of the disease must rely on the regular intervention of authoritative hospitals and experts. After taking conventional medical means (surgery, drugs, radiotherapy, chemotherapy), comprehensively evaluating their own economic situation, and then using immune cell reinfusion conditioning, we can achieve the purpose of consolidating repair, preventing recurrence, improving quality of life, prolonging survival, and finally achieving the purpose of health and disease rehabilitation.
With the continuous breakthrough of regenerative medicine technology, the value of immune cells has become increasingly prominent, which has been perfectly verified in a variety of diseases! It is hoped that more patients can benefit from immune cells.
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